ChemDoodle is described as 'If you are looking for a chemical sketcher or an alternative to your current chemical drawing application, there is no better choice than ChemDoodle. ChemDoodle works on all operating systems (both 32 and 64 bit), has one of the largest feature sets in the industry, has the most' and is an app in the education & reference category. There are nine alternatives to ChemDoodle for a variety of platforms, including Windows, Mac, Linux, Flathub and Flatpak apps. The best ChemDoodle alternative is Chemaxon Marvin, which is free. Other great apps like ChemDoodle are JChemPaint, ChemDraw, ACD/ChemSketch and ChemCanvas.
Marvin suite is a chemically intelligent desktop toolkit built to help you draw, edit, publish, render, import and export your chemical structures and as well as allowing you to convert between various chemical and graphical file formats.
JChemPaint (or JCP for short here) is the editor and viewer for 2D chemical structures developed using the Chemistry Development Kit (CDK).
ChemDraw is a communication suite for managing, reporting and presenting Chemistry research. Produce precise chemical structures with our premier chemical drawing solution.
ACD/ChemSketch is a chemically intelligent drawing interface that allows you to draw almost any chemical structure including organics, organometallics, polymers, and Markush structures. Use it to produce professional looking structures and diagrams for reports and publications.
BKChem is a free (as in free software :o) chemical drawing program. It was conceived and written by Beda Kosata and is currently maintained by Reinis Danne.
XDrawChem is a free software program for drawing chemical structural formulas, available for Unix and Mac OS. It is distributed under the GNU GPL. In Microsoft Windows this program is called WinDrawChem.
speciolab is a modern yet easy-to-use chemical drawing software that is aimed at helping students, companies and other users to draw clean and orderly chemical structures for reports, theses and presentations.
"MedChem Designer 3.0 is a free chemical structure drawing program. MedChem Designer can open SMILES, SDF, MOL, CSK, and RXN file types. Up to 32 compounds can be displayed in one window. Images can be exported in SMILES, SD, MOL, CQF, bitmap, JPG, or PNG formats.
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Because it has a wide toolbox to manipulate chemical structures, it's free and it's easy of use.